Titlebook: COX-2 Blockade in Cancer Prevention and Therapy; Randall E. Harris Book 2003 Springer Science+Business Media New York 2003 Prevention of b

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https://doi.org/10.1007/978-3-319-05410-0 a viable approach for the chemoprevention of colorectal cancer. This chapter will begin with a review of some of the key findings that led to the hypothesis that COX-2 inhibitor therapy inhibits colorectal cancer development followed by a discussion of the prostaglandin (PG) signaling pathways that have been linked to the carcinogenic process.

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2196-9906 onized cancer research. COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op- portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer. The text is divided broadly into five areas. First, an historical over

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Regulation of Expression and Potential Carcinogenic Role of Cyclooxygenase-2 . to the biologically active end products, PGD., PGE., PGF., PGI. (prostacyclin), and other related eicosanoids. These prostanoids contribute to many normal physiological processes including inflammation, pain and fever, and various cancers .

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Cyclooxygenase-2, Prostaglandins, and Colorectal Carcinogenesis a viable approach for the chemoprevention of colorectal cancer. This chapter will begin with a review of some of the key findings that led to the hypothesis that COX-2 inhibitor therapy inhibits colorectal cancer development followed by a discussion of the prostaglandin (PG) signaling pathways that have been linked to the carcinogenic process.