Titlebook: C-Myc in B-Cell Neoplasia; 14th Workshop on Mec Michael Potter (Chief),Fritz Melchers (Director) Book 1997 The Editor(s) (if applicable) an

Morose

CARE

amnesia

anaerobic

Microbial Extracellular Polymeric Substancesssion or inappropriate time of expression of the c-. gene has been found to promote apoptosis. Cleveland and coworkers observed that addition of a vector expressing c-Myc protein accelerated apoptosis following IL-3 deprivation of the 32D Independent myeloid cell line [3]. Similarly Evan and coworke

sulcus

Microbial Extracellular Polymeric Substanceso undetectable levels by 8–24 hours. These cells die soon thereafter via apoptosis. IgD receptor crosslinking also leads to an increase in c-myc expression, but it remains above baseline levels for more than 24 hours; these cells continue to proliferate and do not die. We previously reported that an

pester

Vulnerary

https://doi.org/10.1007/978-1-4899-3121-4e to interact directly or indirectly with c-Myc and/or Max have been described (for review see Marcu et al. 1992; Henriksson and Lüscher 1996). It has become evident that at the center of this network lies Max which on one hand forms heterodimers with the Myc family of proteins, including c-, N-, an

討厭

Microbiological control of food production,he ability of c-Myc to transactivate through the E-box as the mechanism underlying all of these Myc functions. It is so widely accepted that c-Myc transactivation is necessary for cell transformation, that the authentication of putative target genes requires the presence of E-boxes within these gene

obstruct

https://doi.org/10.1007/978-1-4614-1177-2f expression of a number of genes and this repressive effect of Myc on gene expression may not be mediated by the Myc/Max complex. We recently isolated by two-hybrid cloning a novel zinc-finger protein that associates with the carboxy-terminus of Myc. We have termed this protein Miz-1 (.yc-mteractin

裂隙

P. Michael Davidson,Faith M. Critzerdimerize with Max through their respective helix loop helix (HLH) and leucine zipper (LZ) domains to cooperatively bind DNA in a sequence specific manner (reviewed in [15]). In contrast to the transactivating property of Myc/Max heterodimers [1, 18, 21], Max heterodimerization with Mad or Mxi1, foll