Titlebook: Breast Cancer: Scientific and Clinical Progress; Proceedings of the B Marvin A. Rich,Jean C. Hager,Diana M. Lopez Conference proceedings 19

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ALERT

Vincenzo Lattanzio,Giovanni Simonettimammary epithelial cells, mucins appear to be developmentally regulated, and since immunologically related molecules are expressed by over 95% of breast cancers, they represent an important class of markers in differentiation and malignancy.

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Vincenzo Lattanzio,Giovanni Simonettion, we shall (a) review the evidence for the presence of such aberrant fibroblasts in cancer patients, (b) discuss the possible role played by these cells in the pathogenesis of breast cancer, and (c) consider the clinical implications of these findings.

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Myoepithelial and Endocrine Differentiation in Breast Carcinomaical and functional studies. Most human breast carcinomas express glycoproteins such as the Epithelial Membrane Antigen and related antigenic fragments (1), cytoskeletal components (signatedly the cytokeratins 18 and 19) (2, 3) and hormonal receptors (4), also expressed by the normal luminal cells of breast ducts and ductules.

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Mesenchymal-Epithelial Interactions in Normal and Malignant Mammary Cellsal mesenchymal-epithelial relationships have been associated with abnormal development and carcinogenesis (3). In addition, evidence is accumulating to support the concept that the mesenchyme of individuals at high risk for cancer have unique properties (4–8). A large literature provides a foundation that supports these conclusions.