Titlebook: Breast Cancer Stem Cells & Therapy Resistance; Phuc Van Pham Book 2015 The author(s) 2015 BCSC-targeting therapy.cancer cell culture.cance

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Breast Cancer Stem Cells & Therapy Resistance978-3-319-22020-8Series ISSN 2192-8118 Series E-ISSN 2192-8126

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https://doi.org/10.1007/978-3-476-99835-4reast cancers are the milk-secreting cells and duct cells, which drain milk from the lobules to the nipple. However, a small proportion of breast cancers develop from fatty or fibrous tissue. Breast cancer now is the most popular kind of gene mutation related cancer in women. Treatment efficiency of

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https://doi.org/10.1007/978-3-476-99835-4ition in biology, the idea of CSCs has existed for more than 50 years. In recent years, the relations between “stem cells” and “cancer stem cells” gradually explored. Almost studies showed that cancer stem cells could be produced from stem cells with some specific mutations in the genome. However, C

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https://doi.org/10.1007/978-1-4614-5906-4 the National Academy of Sciences of the United States of America 100(7): 3983–3988, 2003)]. At first, BCSCs were defined as a small population of breast cancer cells that could cause breast tumors. These cells were also called tumor-initiating cells. These cells represent only 1–5 % of the tumor. R

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Generalized Stochastic Heat Equationsood system. These cells were considered as origins of metastasis. They closely related to breast CSCs. Some hypothesis demonstrated that circulating tumour cells (CTCs) could be breast CSCs that escaped from the tumours and circulated in the blood. However, they changed the phenotype during invasion