Titlebook: Breast Cancer Risk Reduction and Early Detection; Edward R.‘Sauter,Mary B.‘Daly Book 2010 Springer-Verlag US 2010 Breast.Cancer.Cancer che

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Breast Cancer Chemopreventionuction. All of these trials have capitalized on the known expression of estrogen receptors on many breast cancer cells, and the demonstrated efficacy of selective estrogen receptor modulators (SERMs) to treat breast cancer. Two SERMs, tamoxifen and raloxifene, have been studied extensively in random

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Surgical Management of Inherited Susceptibility to Breast Cancer risk-reducing salpingo-oophorectomy. Over the past decade, increasing data have become available regarding the efficacy of and the adverse effects from these surgical approaches. In this chapter we review the available literature, including the indications for such surgeries, as well as their risks

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Genetic and Molecular Approaches to Imaging Breast Cancerble. Although CT, MRI, and ultrasound have made great strides, none of the current modalities can image oncogene expression directly. No other reliable method is currently available to measure levels of specific receptors or mRNAs in vivo. In contrast to indirect approaches, noninvasive administrati

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Intraductal Approaches: Nipple Aspirate Fluid to Assist in Breast Cancer Detectionto breast examination and imaging studies (mammography supplemented with ultrasound, and magnetic resonance imaging [MRI] for certain indications). Abnormalities found by these techniques require an invasive needle or surgical biopsy to determine if cancer is present. Our approach is to determine no