Titlebook: Breast Cancer Metastasis and Drug Resistance; Progress and Prospec Aamir Ahmad Book 20131st edition Springer Science+Business Media New Yor

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Development of Notch Pathway Inhibitors for Cancer Therapy,ing developed. In this review, we describe the basics of Notch signaling, the role of Notch in normal and cancer stem cells; finally we describe opportunity and challenges in the development of Notch inhibitors as novel targeted agents for cancer patients.

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Epigenetic Factors in Breast Cancer Progression,processes involved in the initiation and progression of breast carcinogenesis. This chapter describes the major epigenetic modifications involved in breast carcinogenesis and use of various epigenetic modulators in preclinical as well as in clinical trials against breast carcinogenesis.

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Understanding Tamoxifen Resistance of Breast Cancer Based on Integrative Bioinformatics Approaches,The analyses reveal that the tamoxifen resistant tumors are highly proliferative and display a distinctive expression profile for genes related to inflammation and angiogenesis compared to tamoxifen sensitive tumors. The bioinformatics analysis also identifies a set of small molecules that may reverse the tamoxifen resistance in breast tumor.

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Utility, Limitations and Lacunae platinum and ruthenium based drugs against breast cancer. Chemical formulae and a brief description of the manifold biological activities of some important such compounds are provided which might be of interest to inorganic chemists, medicinal chemists, biologists, and clinicians alike.

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Gabriele Gaziev,Enrico Finazzi Agròancer. Furthermore, these molecular signatures could not only help to identify new therapeutic targets, but also allow physicians to design more effective and targeted therapeutic strategies for achieving better treatment outcomes of breast cancer patients.

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s and some novel signaling pathways?.Excellent source for of?This volume?comprehensively?covers recent prrogress in breast cancer research. In an effort to successfully treat breast cancer, it is imperative to a) fully understand the disease with all its heterogeneity, b) understand the factors that