Titlebook: Brain Tumors in Children; Amar Gajjar,Gregory H. Reaman,Franklin O. Smith Book 2018 Springer International Publishing AG, part of Springer

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Imaging Children with CNS Tumors,red mental status, CT, even with intravenous contrast, is insufficient for tumor characterization or metastasis detection. CT also carries a low risk of radiation-induced secondary cancers; this risk increases with cumulative dose without a threshold effect (Miglioretti et al. 2013). Furthermore, th

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Predisposition Syndromes to Central Nervous System Cancers, their rarity, genetic predisposition syndromes play a disproportionately important role in the management of children with CNS cancers due to their influence on therapeutic strategies, treatment-related toxicities, and long-term prognosis, and on the need for genetic counseling of families and scre

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Modern Principles of CNS Tumor Classification,guishable tumors can show significant molecular heterogeneity—something that is still under intense investigation. Recent advances in genome and epigenome research have revealed extensive clinically useful features of distinct molecular entities, or subgroups thereof, which will help in the classifi

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Ependymoma,dren and infants have a very poor prognosis. The majority of cases arise within the posterior fossa (70%), followed by the supratentorial region (25%) and the spinal cord (5%). Several independent studies have identified compartment-specific molecular subtypes of ependymomas. Within the posterior fo

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