Titlebook: Bone Toxicology; Susan Y. Smith,Aurore Varela,Rana Samadfam Book 2017 Springer International Publishing AG 2017 Bone Pharmacology.Bone Phy

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AGGER

Bone Physiology and Biologybasic function attributed to the cellular components, the osteoblasts osteocytes and osteoclasts. In the second section, the interplay between these matrix components and the cells will be discussed in the context of skeletal growth, skeletal adaptation (modeling), and skeletal maintenance (bone rem

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Specific Considerations for Bone Evaluations for Pediatric Therapeuticsin the requirements for juvenile toxicity testing of pharmaceuticals and biopharmaceuticals since 1998, with regulatory agencies commonly requiring nonclinical studies; particular emphasis is often being placed on evaluations of growth and the development of the skeleton. A number of therapeutic cla

custody

Animal Models in Bone Researchlating those effects into effects in humans is required, because of the skeletal intermediary organization that only exists in vivo. Bone cells function in vivo within the intermediary organizations of modeling, which controls bone growth and shape changes, and remodeling, which controls bone renewa

MEET

Biochemical Markers of Bone Turnovere skeleton level and to investigate potential mechanisms. The goal of this chapter is to describe the biochemical markers of bone turnover, consisting of markers of bone formation and bone resorption, considered important when conducting safety assessments in a preclinical setting. The bone formatio

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Pituitary Hormone-Driven Mechanism for Skeletal Loss over the past decade that these hormones and their receptors have more ubiquitous functions. Organs, such as the skeleton, are regulated by and respond to pituitary hormones, particularly when circulating levels are perturbed in disease. Additionally, certain pituitary hormones are also expressed i