Titlebook: Bone Metastasis and Molecular Mechanisms; Pathophysiology Gurmit Singh (Director of Research, Professor of P Book 2004 Springer Science+Bus

Entreaty

The Role of Bisphosphonates in Bone Metastasis,igure 1). These compounds were first synthesized in Germany in 1865. Their initial use was industrial (textile, fertilizer and oil industries) and for prevention of mineral scaling (due to their ability to inhibit calcium carbonate precipitation). The biological properties of these compounds, however, were not explored until the 1960’s (1, 2).

托運(yùn)

https://doi.org/10.1007/978-1-4020-2036-0angiogenesis; bisphosphonates; bone marrow; cancer; macrophages; metastasis; pain; pathophysiology; prostate

Antioxidant

污點(diǎn)

Springer Series in Materials Sciencete of metastasis of some other cancers, including prostate. Bone metastases in breast cancer are predominantly osteolytic due to the resorption of bone following excessive activation of osteoclasts. This leads to major clinical problems including severe pain, hypercalcemia, bone fractures and nerve-

滴注

https://doi.org/10.1007/978-3-540-70766-0ew spontaneous models of bone metastasis despite the fact that rodents (rats and mice) and other animals (dogs and cats) often spontaneously develop cancer. Therefore, most experimental models of bone metastasis in rodents require injection or implantation of neoplastic cells into orthotopic locatio

態(tài)度暖昧

Pruritus

electrolyte

Springer Series in Materials Scienceastasis to the bone marrow. The extensive changes induced by cancer metastasis in bone (either lytic, or more rarely, sclerotic) represent secondary changes induced to fulfill the need of cancer cells for their anti-homeostatic growth. A common biological paradigm — “the seed and the soil” — is used

TRUST

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