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Titlebook: Blood-Brain Barrier; Drug Delivery and Br David Kobiler,Shlomo Lustig,Shlomo Shapira Book 2001 Springer Science+Business Media New York 200

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發(fā)表于 2025-3-21 18:27:24 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
期刊全稱(chēng)Blood-Brain Barrier
期刊簡(jiǎn)稱(chēng)Drug Delivery and Br
影響因子2023David Kobiler,Shlomo Lustig,Shlomo Shapira
視頻videohttp://file.papertrans.cn/190/189346/189346.mp4
圖書(shū)封面Titlebook: Blood-Brain Barrier; Drug Delivery and Br David Kobiler,Shlomo Lustig,Shlomo Shapira Book 2001 Springer Science+Business Media New York 200
影響因子The vasculature of the central nervous system (eNS) is characterized by the existence of the blood-brain barrier (BBB), which can be regarded as both an anatomical and physiological phenomenon. The BBB is formed by a complex cellular system of endothelial cells, astroglia, pericytes, perivascular macrophages and a basal membrane, although the anatomic substrate of the BBB is the interendothelial tight junctions that form a continuous sealing. The BBB serves as an exquisitely controlled, functional gate to the eNS. It not only protects the brain from agents in the blood that could impair neurological function, but also controls the influx and efflux of numerous substances to maintain proper homeostasis and provide the brain with necessary nutrients. The structural and functional integrity of the BBB was shown to be dramatically altered during various diseases of the eNS, including neoplasia, ischemia, trauma, hypertension, inflammation and epilepsy. Recent years research has partially elucidated the mechanisms underlying the development of some of these brain disorders as well as the pathways used by different pathogens, like bacteria and viruses, to initiate eNS infections. The dev
Pindex Book 2001
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書(shū)目名稱(chēng)Blood-Brain Barrier影響因子(影響力)




書(shū)目名稱(chēng)Blood-Brain Barrier影響因子(影響力)學(xué)科排名




書(shū)目名稱(chēng)Blood-Brain Barrier網(wǎng)絡(luò)公開(kāi)度




書(shū)目名稱(chēng)Blood-Brain Barrier網(wǎng)絡(luò)公開(kāi)度學(xué)科排名




書(shū)目名稱(chēng)Blood-Brain Barrier被引頻次




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書(shū)目名稱(chēng)Blood-Brain Barrier年度引用




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書(shū)目名稱(chēng)Blood-Brain Barrier讀者反饋




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Book 2001ia, ischemia, trauma, hypertension, inflammation and epilepsy. Recent years research has partially elucidated the mechanisms underlying the development of some of these brain disorders as well as the pathways used by different pathogens, like bacteria and viruses, to initiate eNS infections. The dev
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Novel Endothelial-Mediated Responses Associated with Microcirculation and BBB Function,7). Our initial studies demonstrated that NO was involved in the postischemic hypoperfusion observed in animal models of cerebral ischemia (Spatz, .,1995b). This effect was related to increased levels of ET-1 in the cerebrospinal fluid (CSF). Treatment with ET-1 receptor antagonists abolished the hy
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發(fā)表于 2025-3-22 09:38:59 | 只看該作者
Modulators of Blood-Brain Barrier (BBB) Permeability: , and , Drug Transport to the Brain,ult in increased or decreased paracellular and/or transcellular transport of compounds to the brain. Under such conditions, upregulated transcellular transport may provide a key to target drugs selectively to the BBB and subsequently into the brain. In the BBB Research Group of the Division of Pharm
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發(fā)表于 2025-3-22 16:02:00 | 只看該作者
Controlled Modulation of the Blood-Brain and Blood-Tumor Barrier Using Novel Lipid Mimetic Compoundl transiently open the BBB and facilitate entry of a particular drug or agent to the brain (Abbot). Modulation of the BBB with bioactive molecules in contrast to osmotic disruption is appearing as an effective technique. Some limited clinical success has been reported with this approach in the perme
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Stress, Pyridostigmine and the Blood Brain Barrier,ition, fatigue, sleep disturbance, confusion), which could not be easily explained by the effects of a compound that does not enter the CNS. The controversy around the “Gulf war syndrome” was further complicated by the suggestion that stress exposure (physical conditions, combat related anxiety, per
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