Titlebook: Blood-Brain Barrier Permeability Changes after Subarachnoid Haemorrhage: An Update; Clinical Implication Antonino F. Germanò,Francesco Toma

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The Concept of the BBB: A Historical Perspective,he early years of neurosurgery, when neurosurgeons tried to cope with a multitude of life-threatening complications, such as brain oedema, the relation of which to the BBB was not yet recognised. The attitude of neurosurgeons toward the barrier may since then be characterised as an aifair of love an

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Anatomy of the BBB,ate a depression: the tips of this structure fuse in order to develop a tube. During the early stages, a single cell layer constitutes this tube. During the developmental stages, the differentiation phenomena determine the creation of flexures, folds, depressions, invaginations, and thickening of th

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Pathophysiology of BBB,omprising the BBB needs to be viewed as two separate impermeable cellular membranes, one on the inside of the vessel wall (luminal side) and the other on the outside (abluminal side) separated by 300-to 500-nm thick cytoplasm. The surface area of cerebral capillary endothelium is approximately 100 c

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BBB Dysfunction after SAH,ion, massive increase in intracranial pressure with a consequent decrease in cerebral perfusion pressure and tissue ischaemia, local increase in tissue pressure with microvascular compression, or the effects of vasoactive factors within the cerebrospinal fluid released from blood breakdown products.

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Strategies for Pharmacological Intervention,id haemorrhage. Nimodipine is a highly lipid-soluble dihydropyridine derivative that readily crosses the blood-brain barrier. In animal studies, nimodipine has been shown to be effective in increasing cerebral blood flow; preventing vasoconstriction attributable to sympathetic stimulation, hypocapni

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