Titlebook: Blood-Brain Barrier; Tatiana Barichello Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Neuronal progenitor c

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Approximate Inference Via the EM Algorithmthe difficulty in delivering diagnostic and therapeutic molecules across the blood-brain barrier (BBB) and into the brain. This chapter describes these and other challenges and the progress that has been made in transporting molecules into the brain. The pathways that molecules can take to cross the

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An Introduction to Bayesian Inferencetive function, BBB regulates entry of nutrients into the central nervous system by selective transport and metabolism of blood- and brain-borne substances. Successful modeling of BBB in vitro is established since 1970s and has been used to study mechanisms of transport, cellular interaction, and gen

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https://doi.org/10.1007/978-3-319-72425-6e performed in vivo. However, major limitations of this approach, including limited translational significance to human patients, high cost, time, and labor to develop the appropriate model (e.g., transgenic or inbred models), have greatly favored the parallel development of in vitro models. These a

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https://doi.org/10.1007/978-3-319-72425-6ly mimic the physiological complexity of the in vivo BBB continues to be a challenge, however. To meet this challenge, in vitro BBB models have evolved significantly over the last three decades, from static monocultures to dynamic multicellular flow-based systems. In this chapter, we initially focus

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Beyond First-Order Truthlikeness, in vitro cellular barriers for transport studies. TEER measurement has advantages over traditional permeability measurements as a quick, label-free, and non-invasive method. TEER measurement has an added advantage that it can be performed in real -time if the measurement electrodes are integrated i