| 期刊全稱 | Blood Cell Biochemistry | | 期刊簡稱 | Hematopoietic Cell G | | 影響因子2023 | Anthony D. Whetton,John Gordon | | 視頻video | http://file.papertrans.cn/190/189298/189298.mp4 | | 學(xué)科分類 | Blood Cell Biochemistry | | 圖書封面 |  | | 影響因子 | Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress has been made in erythropoietin research, which demon- strates the general trends in this field of study. Erythropoietin was purified to homogeneity by 1977 (from enormous quantities of urine from aplastic anemia patients). Subsequently, the gene for erythropoietin has been cloned (1985), and massive quantities of this growth factor have been produced for clinical trials (late 1980s onward). Erythropoietin has become established as a pharmaceutical product of great value in the treatment of a number of diseases, most notably chronic renal failure. Once the ligand had been cloned, interest turned to the erythropoietin receptor, which was cloned in 1989. Since then, structure/ function studies have been performed on receptor mutants, cellular signaling events down- stream from the occupied receptor have been identified, and the specific producer cell types and molecular stimuli for erythrop | | Pindex | Book 1996 |
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