Titlebook: Bisphosphonates and Tumor Osteolysis; Kurt W. Brunner,Herbert Fleisch,Hans-J?rg Senn Conference proceedings 1989 Springer-Verlag Berlin He

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,Einführung in die Linsentheorie (27–46),tal aspects as well as clinical applications of these compounds. Literature is essentially limited to one reference, usually the original report. For two recent reviews, weighted somewhat differently and with more extensive references, see Fleisch (1983) and Francis and Martodam (1983).

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Bisphosphonates: A New Class of Drugs in Diseases of Bone and Calcium Metabolism,tal aspects as well as clinical applications of these compounds. Literature is essentially limited to one reference, usually the original report. For two recent reviews, weighted somewhat differently and with more extensive references, see Fleisch (1983) and Francis and Martodam (1983).

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Pathophysiological Aspects and Therapeutic Approaches of Tumoral Osteolysis and Hypercalcemia,ssociated with nausea, vomiting, dehydration, mental disturbance, confusion, and eventually coma. The appropriate management of tumor-mediated bone osteolysis and hypercalcemia requires an appreciation of the various factors implicated in bone remodeling and in Ca homeostasis (Mundy and Roodman 1987; Bonjour et al. 1987).

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,Fortsetzung der Linsentheorie (59–61),ssociated with nausea, vomiting, dehydration, mental disturbance, confusion, and eventually coma. The appropriate management of tumor-mediated bone osteolysis and hypercalcemia requires an appreciation of the various factors implicated in bone remodeling and in Ca homeostasis (Mundy and Roodman 1987; Bonjour et al. 1987).

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Bisphosphonates: A New Class of Drugs in Diseases of Bone and Calcium Metabolism,etabolism. Three are on the market today, while others are under clinical or preclinical investigation. This chapter will cover chemical and experimental aspects as well as clinical applications of these compounds. Literature is essentially limited to one reference, usually the original report. For

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Pathophysiological Aspects and Therapeutic Approaches of Tumoral Osteolysis and Hypercalcemia,ents of bone mineral (Rodman and Sherwood 1978; Mundy and Martin 1982). The clinical consequences of these disturbances can be dramatic on the degree of morbidity of cancer patients. Bone metastasis and osteolysis are a major source of pain, pathological fractures, and disability. Hypercalcemia is a

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