Titlebook: Bispecific Antibodies; Roland E. Kontermann Book 2011 Springer-Verlag Berlin Heidelberg 2011 Cancer therapy.Hybridoma.Immunoglobulin.Immun

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Die Technik der kystoskopischen Untersuchungble two different monospecific binding units into one molecule, two-in-one antibodies are dual-specific antibodies that can be produced as conventional IgG, in which each of the two identical Fab arms recognizes two distinct antigen epitopes. The first proof-of-concept two-in-one bH1 has been select

OMIT

Pathologie der Harnleitermündung existing repertoires of such agents as produced by genetic engineering alone, we envisioned and developed the Dock-and-Lock (DNL) method, which enables site-specific conjugation of two modular components only with each other, producing a covalent construct of defined composition with retained bioac

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Pathologie der Harnleitermündungherapy. For redirecting cytotoxic effector cells against tumors, typically the first binding site of a bispecific antibody recognizes a tumor-associated antigen, whereas the second site engages a stimulatory trigger molecule on effector cells. The adequate choice of the trigger molecule offers the o

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Technik des Harnleiterkatheterismusrty enables the development of therapeutic strategies that are not possible with conventional monoclonal antibodies (mAbs). Advances in antibody engineering and the expanding knowledge of antigen profiling on malignant cells have provided innovative solutions for the development of various formats o

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Technik des Harnleiterkatheterismuss are being pursued, including long-term gene correction of monogenetic diseases, eradication of tumor cells in cancer patients, or genetic vaccination for infectious diseases. Bispecific antibodies and gene therapy are connected in two ways. First, bispecific antibodies are tools of interest for th

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Die Technik der kystoskopischen Untersuchungity to simultaneously bind to a specific antigen and a given detection moiety enables them to function as excellent bifunctional immunoprobes in diagnostic assays. BsMAb are being exploited for the development of simple, rapid, and highly sensitive immunoassays for diagnosis of bacterial and viral i