Titlebook: Biopharmaceutical Applied Statistics Symposium; Volume 3 Pharmaceuti Karl E. Peace,Ding-Geng Chen,Sandeep Menon Book 2018 Springer Nature S

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ICSA Book Series in Statisticshttp://image.papertrans.cn/b/image/188313.jpg

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Targeted Learning of Optimal Individualized Treatment Rules Under Cost Constraints,We consider a general resource-allocation problem, namely, to maximize a mean outcome given a cost constraint, through the choice of a treatment rule that is a function of an arbitrary fixed subset of an individual’s covariates.

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Uncovering Fraud, Misconduct, and Other Data Quality Issues in Clinical Trials,This chapter summarizes statistical and graphical approaches to evaluate data quality in clinical trials. Distinguishing between fraud, misconduct, and carelessness for data aberrations is discussed. Several methods are illustrated using a clinical trial of patients who experienced an aneurysmal subarachnoid hemorrhage.

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