Titlebook: Biomarkers for Alzheimer’s Disease Drug Development; Robert Perneczky Book 2024Latest edition The Editor(s) (if applicable) and The Author

躺下殘殺

remission

https://doi.org/10.1007/978-3-531-92696-4eration of new hypotheses regarding the mechanistic and functional significance of lipid and metabolite alterations in neurodegenerative disorders while also facilitating the discovery of new biomarkers to support drug development.

sundowning

Metamorphosis

Analysis of Resting-State Functional Magnetic Resonance Imaging in Alzheimer’s Diseasen this chapter, we presented the common methods that have been applied in rs-fMRI literature, focusing on the studies on individuals in the continuum of AD. The key methodological aspects will be addressed that comprise acquiring, processing, and interpreting rs-fMRI data. More, we discussed the current and potential implications of rs-fMRI in AD.

browbeat

Acetabulum

Cryptic

Alzheimer’s Disease Prevention and Treatment Based on Population-Based Approachesentia prevention, coordinated global efforts are needed to utilize existing cohorts and resources effectively and efficiently. This chapter provides an overview of current research on risk and protective factors for AD and dementia and discusses the opportunities and challenges associated with population-based approaches.

中止

Foreshadow

Mass Spectrometry-Based Metabolomics Multi-platform for Alzheimer’s Disease Researchgraphy and gas chromatography. These procedures have been optimized for the analysis of multiple biological samples from human patients and transgenic animal models, including blood serum, various brain regions (e.g., hippocampus, cortex, cerebellum, striatum, olfactory bulbs), and other peripheral organs (e.g., liver, kidney, spleen, thymus).

overrule

Diffusion Tensor Imaging in Alzheimer’s Studieses examining correlations with behavioral variables is also included. Our main message is to caution against the overinterpretation of diffusion metrics and to favor analyses that focus on regions of interest or major white matter tracts for biomarker studies in AD.