Titlebook: Biology of Growth Factors; Molecular Biology, O Jeffrey E. Kudlow,David H. MacLennan,Avrum I. Gotl Book 1988 The Editor(s) (if applicable)

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The , Pathway: A Model for the Control of Proliferation in Animal Cellsof the control of proliferation within the organism. While the discussion will center primarily upon a presentation of data, hypotheses relating to these data will also be included. In many cases, the hypotheses are only speculative at present.

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The Endosomal Apparatus and Transmembrane Signallingmonstrated that the endosomal components are not lysosomes, . that a sequential transport of ligands and receptors among endosomal components can be observed, . and that morphologically different microdomains can be observed in continuous structures segregating ligands (vesicular) from receptors (tubular)..

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Book 1988onse. Abnormal production of these growth factors, their receptors or intracellular med!ators of their action may lead to disease states including oncogenesis. This volume will focus on exciting developments in defining the precise molecular lesions that permit the conversion of controlled prolifera