Titlebook: Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates; W. E. G. Müller,H. C. Schr?der Book 1994 Sprin

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Progress in Molecular and Subcellular Biologyhttp://image.papertrans.cn/b/image/187453.jpg

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Activation of the dsRNA-Dependent Kinase,tein kinase, is an interferon-induced serine/threonine protein kinase. It is uniquely distinguished from other protein kinases in that its activation to a functional enzyme, and in some cases prevention of its activation, is dependent on RNAs containing accessible double-stranded structures. However

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Double-Stranded RNAs as Gene Activators,d that dsRNA is the active agent in an extract of a . preparation which, following injection into rabbits, induces interferon (IFN) in serum. They also showed that various natural (i.e. reovirus genomic RNA) or synthetic (i.e. poly rI:rC) dsRNAs induce IFN-α/β in animals and cultured animal cells (F

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Mechanism of the Antiretroviral Effect of dsRNA,osynthesis of interferon (IFN), production of 2′,5′-oligoadenylate (2-5A), ribonuclease L (RNase L) activity and different cell-mediated immune functions. A restriction of available bioactive dsRNA (or of dsRNA-dependent enzymes) may play an important role in the disease progression. The results sum

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The Antiviral Activity of RNA-Dye Combinations,ogenic, and specific for viral functions. Effective viral chemotherapy has been hindered because viruses employ host cell systems to replicate. Recent advances in molecular virology provide a rational basis for the development of antiviral compounds that will interfere with biochemically defined, vi

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