Titlebook: Biological Reactive Intermediates—II; Chemical Mechanisms Robert Snyder,David J. Jollow,Stephen L. Longacre Book 1982 The Editor(s) (if ap

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The Heme Protein P-450 in Oxygen Activation: Carbon Monoxide Inhibition and Photochemical Action Spes). Atmospheric oxygen, O., and reducing equivalents, provided by reduced pyridine nucleotides, are co-substrates in these reactions in which, in a formal sense, one or both of the atoms of the oxygen molecule are inserted into the reaction products (monooxygenation and dioxygenation, respectively).

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Deutsche Gesellschaft für Chirurgie, 1974; Jansson and Schenkman 1975, 1977). Less clear is the role of cytochrome .. in the NADPH-supported and NADH-synergized reactions. This synergism has been shown to require cytochrome .. by the use of antibodies (Sasame et al., 1973, Mannering et al., 1974, Jansson and Schenkman, 1977), but the mechanism has remained to be elucidated.

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Fate of EpdxidesHeidelberger, 1975; Gelboin et al., 1972). This review first describes structure-activity relationships for the mutagenicity of some epoxides and then outlines some findings on the metabolic control of the concentration of such epoxides by a number of enzymes.