Titlebook: Biological Reactive Intermediates IV; Molecular and Cellul Charlotte M. Witmer,Robert R. Snyder,I. Glenn Sipe Book 1991 The Editor(s) (if a

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Bioactivation of Xenobiotics by Flavin-Containing Monooxygenasese prosthetic group. The enzyme is apparently present within the cell in this form and any soft nucleophile that can gain access to the enzyme-bound oxygenating intermediate will be oxidized. Precise fit of substrate to enzyme is not necessary, and FMO catalyzes at the same maximum velocity the oxida

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S-Thiolation of Protein Sulfhydrylstabolically labile and the rapid “dethiolation” of these proteins by several reductive processes (Park and Thomas, 1989) prevents lasting damage to the protein. Thus, the dynamic modification of proteins by S-thiolation/dethiolation processes represents one of the more important cellular mechanisms

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Monitoring Human Exposure to Environmental Carcinogensividuals with a specific phenotype (e.g. poor metabolizers of debrisoquin or lacking specific glutathione transferase activity) among cancer cases than controls (Ayesh et al. 1984, Seidegard et al. 1986).

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,Lagerung von Spiralkegelr?dern,The toxic effects of many xenobiotics are very often not due to the parent compound itself but to reactive intermediates or metabolites formed . inside the cell. These reactive species may bind covalently to cell proteins leading to various cell disorders and eventually to toxic effects.

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Formation of Reactive Metabolites and Appearance of Antiorganelle Antibodies in ManThe toxic effects of many xenobiotics are very often not due to the parent compound itself but to reactive intermediates or metabolites formed . inside the cell. These reactive species may bind covalently to cell proteins leading to various cell disorders and eventually to toxic effects.

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