Titlebook: Biological Reactive Intermediates; Formation, Toxicity, David J. Jollow,James J. Kocsis,Thomas Walle Book 1977 Springer Science+Business Me

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Biochemical Aspects of Toxic Metabolites: Formation, Detoxication, and Covalent Bindingcent years. It is now appreciated that reactive alkylating, arylating, or acylating derivatives may arise during the metabolism of xenobiotics and that the covalent binding of these reactive metabolites to cellular macromolecules may initiate events leading to the destruction of specific cellular co

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Discussionors. Miller replied that the enzyme activity is not very inducible by 3-MC or phenobarbital. He considered the enzyme to be essentially the same as the primary and secondary amine oxidase isolated by Ziegler from pig liver. The purified flavoprotein enzyme, supplied by Ziegler, catalyzes the .-hydro

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