Titlebook: Biochemistry and Molecular Genetics of Cancer Metastasis; Proceedings of the S Karoly Lapis,Lance A. Liotta,Alan S. Rabson Conference proce

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Kristin C. Thompson,Richard J. Morrisnd after ten such . selections, subline RAW117-H10 was established (5). The RAW117-H10 variant subline is highly metastatic and rapidly kills its host. For example, H10 cells form more than 200 times as many gross surface liver tumor nodules after intravenous or subcutaneous injection than does the parental RAW117-P line (5, 6, 9, 10).

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Peptide Fragments of Fibronectin and Laminin: Role in Cell Adhesion and Inhibition of Experimental Tnts. The cells must enter the capillaries or vessels at the primary site, get into the blood stream, travel to a distant site, adhere to endothelial or subendothelial structures, migrate through the basement membrane, and move and grow at this secondary locus (see reviews 1–4).

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Parole and Community Supervisionient’s tumor. Antibodies to the same metastatic factors could be applied to radioscintography to localize clinically silent metastases. Finally, pharmacologic agents which bind to and/or block the metastatic factors may be ultimately useful in the therapy of metastases.

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Social-Psychological Theories of Delinquencyds itself readily to molecular genetic analyses of metastatic properties of cells (1). In this review, this assay and the advantages that it offers to molecular studies will be discussed. We have used this assay to begin an examination of genes that can contribute to the metastatic phenotype; some of these studies will also be described here.

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