Titlebook: Biochemistry and Cell Biology of Ageing: Part III Biomedical Science; J. Robin Harris,Viktor I. Korolchuk Book 2023 The Editor(s) (if appl

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Mitochondrial DNA Mutations and Ageing,ude carbohydrate and fatty acid metabolism to generate cellular energy through oxidative phosphorylation, apoptosis, cell signalling, haem biosynthesis and reactive oxygen species production. Mitochondrial dysfunction is a feature of many human ageing tissues, and since the discovery that mitochondr

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The Proteasome and Ageing, proteins for cellular protection. Generally, the proteasome targets substrate proteins that are marked by attachment of multiple ubiquitin molecules. In various types of cells in an organism, damage to proteins occurs both from internal sources such as reactive oxygen species and from external ones

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