Titlebook: Bioactive Sphingolipids in Cancer Biology and Therapy; Yusuf A. Hannun,Chiara Luberto,Lina Marie Obeid Book 2015 Springer International Pu

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Sphingolipids in the Pathogenesis of Head and Neck and Lung Cancers: Translational Aspects for Theran addition to being important for membrane structures. With the identification of enzymes involved in metabolism of various bioactive molecules of the sphingolipid pathway, a better and broader understanding has been gained of how cells control signaling events, such as proliferation and apoptosis,

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Dealing

Systems Biology Approaches for Studying Sphingolipid Signalingee other chapters in this volume). However, much remains unknown in terms of the signaling mechanisms and downstream pathways affected by sphingolipids in cancers, such as which sphingolipid pathway is involved, which sphingolipid species contributes to a specific cancer’s biologic response, and whi

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Sphingoproteomics: Proteomic Strategies to Examine Sphingolipid Biologyclude roles in inflammation, proliferation, survival, and metastasis. Sphingolipids can exert these effects through an increasing number of identified interacting cellular targets. To facilitate the understanding of the intrinsic biology of sphingolipids and the development of sphingolipid-based the

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Utilization of Caged Ceramide and Ceramide 1-Phosphate Analogs for Monitoring Cellular Events after es, ceramide and ceramide 1-phosphate. Biophysical studies were carried out after a 6-bromo-7-hydroxycoumarinyl-ceramide conjugate was inserted into model bilayer membranes. Uncaging with long-wavelength UV light liberated .-palmitoylceramide, and reorganization of lipid domains in the bilayer was m

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978-3-319-35371-5Springer International Publishing Switzerland 2015

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