Titlebook: BetaSys; Systems Biology of R Bernhelm Boo?-Bavnbek,Beate Kl?sgen,Erik Renstr?m Book 2011 Springer Science+Business Media, LLC 2011 diabete

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Book 2011.BetaSys. uses the example of regulated exocytosis in pancreatic β-cells, and its relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications..

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978-1-4614-2815-2Springer Science+Business Media, LLC 2011

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Elke Schierer,Annette Rabe,Birgit Gronertill remain unanswered regarding how structure–function relationships change in the β-cell under different physiological conditions and how such changes contribute to the onset/progression of β-cell dysfunction and/or death. To address these key questions, we have pioneered a number of novel approac

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DEAF

Institutioneller Wandel durch Lernprozessebegun to unravel the granule proteome in ever-increasing detail. Emerging data complement the results from the other approaches that have been applied to understand the granule. This chapter will explore the current state of knowledge in the field and the implications of emerging proteomic data for

DOLT

The Mathematical Microscope – Making the Inaccessible Accessibleical modelling is discussed for type 1 and type 2 diabetes, depression, cardiovascular diseases and the interactions between the combinations of these, the so-called grey triangle in the metabolic syndrome.

Decimate

Mapping the β-Cell in 3D at the Nanoscale Using Novel Cellular Electron Tomography and Computationaltill remain unanswered regarding how structure–function relationships change in the β-cell under different physiological conditions and how such changes contribute to the onset/progression of β-cell dysfunction and/or death. To address these key questions, we have pioneered a number of novel approac