Titlebook: Beneficial Effects of Endotoxins; Alois Nowotny Book 1983 Springer Science+Business Media New York 1983 Colon.Lipid.Polysaccharid.bacteria

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Stimulation of Immunomodulatory Factors by Bacterial Endotoxins and Nontoxic Polysaccharides, either enhance or suppress the immune response, as well as modify the nature of the response. In this regard, many studies have been performed concerning the adjuvant effects of cell wall-derived lipopolysaccharides (LPS) from gram-negative bacteria. Various laboratories have shown that LPS can bot

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Book 1983 was so widespread that the high expectations had to be followed by disillusionment. Since then, in- terest in endotoxins experienced a few more oscillations, with varying wavelengths and amplitudes, the latest being triggered by the mitotic effect of endotoxin. This led to justified excitement amon

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Possibilities for Use of Endotoxin in Compromised Subjects,only I had the means of creating fever artificially, I should be able to cure all illnesses” (Westphal ., 1977). Over 2000 years later, the pyrogenic principle was found to be endotoxin. Fever therapy using whole gram-negative microorganisms had been in use for about 50 years when Boivin . (1933) described a method to purify the endotoxic material.

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Klaus Friese,Axel Sch?fer,Herbert Hofner ., 1971; Pusztai-Markos, 1975). This tolerance has been manifested in an immunologically nonspecific manner, where endotoxic shock could be prevented by previous applications of small doses of endotoxin or endotoxin derivatives.

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Heinrich Schmidt,Cihan Papan,Johannes Hübnerame time or within a few days after antigen administration, but a depressed antibody response occurred if endotoxin preceded antigen. Thus, these early investigations demonstrated the dual nature of the effect of endotoxin on the immune response.

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