Titlebook: Behavioral Pharmacology of the Cholinergic System; Mohammed Shoaib,Tanya L. Wallace Book 2020 Springer Nature Switzerland AG 2020 Nicotini

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Involvement of Nicotinic Receptors in Working Memory Function, prefrontal cortex is particularly critical for rule representation and working memory, or the ability to hold information “in mind” in the absence of sensory input. Emerging evidence supports a prominent and permissive role for acetylcholine in these excitatory circuits, through actions at choliner

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Cholinergic Receptors and Addiction,ety is the use of tobacco products which contain nicotine. This addiction can be associated with specific receptors in the brain that respond to the natural neurotransmitter acetylcholine. These nicotinic acetylcholine receptors (nAChR) are ligand-gated ion channels formed by the assembly of one or

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Behavioral and Molecular Basis of Cholinergic Modulation of Pain: Focus on Nicotinic Acetylcholine and α9α10 nAChR subtypes have been investigated as potential targets to treat pain. The nAChRs are distributed on the pain transmission pathways, including central and peripheral nervous systems and immune cells as well. Several agonists for α4β2? nAChR subtypes have been investigated in multiple a

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,An Evolving Therapeutic Rationale for Targeting the α7 Nicotinic Acetylcholine Receptor in Autism Sturation and maintenance of cholinergic neurons, have been described in postmortem brains of persons with autism spectrum disorder (ASD). Further, microdeletions of the 15q13.3 locus that encompasses ., the gene coding the α. nicotinic acetylcholine receptor (α. nAChR), are associated with a spectru