Titlebook: Basic Aspects of Receptor Biochemistry; Proceedings of the I Menek Goldstein,Kurt Jellinger,Peter Riederer Conference proceedings 1983 Spri

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Neurotransmitter Related Immunocytochemistry of the Human Central Nervous System,tibodies to tyrosine hydroxylase (TH) to provide an atlas of human catecholaminergic (CA) neurons. A striking increase in complexity of CA neurons is seen in the human mesencephalon when compared with lower animals. Not only synthetic enzymes but also neurotransmitters themselves can be detected. An

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Studies on the Neurotransmitter Binding to Pig Brain Microvessels,y by marker enzyme determination, light and electron microscopy. Binding properties of .H-flunitrazepam were studied in different brain regions. Kinetic studies of .H-flunitrazepam showed B. values of 0,42 ± 0,3 pmol/mg protein and K.-values of 1,26 ± 0,6 nM and were compared to a synaptosomal membr

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Energetics of Ligand Binding to Receptors, changes in the receptors that this induces. Although the effects of chemical modifications of ligands on their affinity for receptors have been intensively studied in several systems, the influence of such changes upon the ability of ligands to induce the conformational changes in receptors that ar

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Receptor Blockade and Synaptic Function,o interacts with systems which act to remove the substance. At no time is there an equilibrium, and it is inappropriate to apply equilibrium kinetics to predict the consequences of modifying the system, .. by blocking receptors. A mathematical model predicts that the subsynaptic response to each pac

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