| 期刊全稱 | Bacterial Sensors | | 期刊簡(jiǎn)稱 | Synthetic Design and | | 影響因子2023 | Jan Roelof Meer | | 視頻video | http://file.papertrans.cn/181/180321/180321.mp4 | | 學(xué)科分類 | Synthesis Lectures on Synthetic Biology | | 圖書封面 |  | | 影響因子 | Bacterial reporters are live, genetically engineered cells with promising application in bioanalytics. They contain genetic circuitry to produce a cellular sensing element, which detects the target compound and relays the detection to specific synthesis of so-called reporter proteins (the presence or activity of which is easy to quantify). Bioassays with bacterial reporters are a useful complement to chemical analytics because they measure biological responses rather than total chemical concentrations. Simple bacterial reporter assays may also replace more costly chemical methods as a first line sample analysis technique. Recent promising developments integrate bacterial reporter cells with microsystems to produce bacterial biosensors.This lecture presents an in-depth treatment of the synthetic biological design principles of bacterial reporters, the engineering of which started as simple recombinant DNA puzzles, but has now become a more rational approach of choosing and combining sensing, controlling and reporting DNA ‘parts‘. Several examples of existing bacterial reporter designs and their genetic circuitry will be illustrated. Besides the design principles, the lecture also fo | | Pindex | Book 2011 |
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