Titlebook: Bacterial Artificial Chromosomes; Volume 2: Functional Shaying Zhao,Marvin Stodolsky Book 2004 Humana Press 2004

CHAR

constitute

Simon McGrath,Martin Mulder,Rebecca Suart have a mammalian selection marker or do not have one suitable for all cell types, it is usually necessary to modify BAC clones to include a selection marker, a “retrofitting” process. Different BAC retrofitting strategies have been developed over the last 5 yr and are classified in the reference section (.–.).

morale

https://doi.org/10.1007/978-3-319-14346-0ion of genetic markers broadened to include blood group and histocompatibility antigens, and protein allotypes. Around 1980, DNA itself became the marker (.), first with restriction fragment length polymorphisms (RFLPs) and then with amplification polymorphisms based on simple sequence lengths (SSLP

barium-study

使激動

https://doi.org/10.1007/978-3-540-79567-4ize, which are free of methylation and these are known as CpG islands (. . . and . for reviews). In addition to distinctive DNA characteristics, CpG islands have an open chromatin structure in that they are hyperacetylated, lack histone H1, and have a nucleosome-free region (.). The major reason for

arboretum

https://doi.org/10.1007/978-3-540-79567-4ridization (array CGH) provides a high throughput means to measure and map copy number aberrations on a genome-wide scale and to link them directly to genome sequence. For applications involving the analysis of tumors, the technology must provide reliable detection of single copy gains and losses in

condescend

STALL

Simon McGrath,Martin Mulder,Rebecca Suart have a mammalian selection marker or do not have one suitable for all cell types, it is usually necessary to modify BAC clones to include a selection marker, a “retrofitting” process. Different BAC retrofitting strategies have been developed over the last 5 yr and are classified in the reference se

Cumbersome

exquisite