Titlebook: BLyS Ligands and Receptors; Michael P. Cancro Book 2010 Humana Press 2010 Antigen.autoimmunity.diseases.pathogenesis.pathophysiology.physi

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Gregg D. Cappon,Donald G. Stump continually provided by either tonic or antigen-mediated BCR signals and other trophic factors. B-cell-activating factor (BAFF) has emerged as a key growth factor for B lymphocytes. Through its interaction with a TNF-R family member, BAFF-R or BR3, BAFF promotes survival of both immature and mature

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https://doi.org/10.1007/978-981-99-1659-7tain self-tolerance, B cells that express antigen receptors with significant reactivity against self-antigens are prevented from receiving or responding to these survival signals. The great majority of B cells produced from bone marrow precursors fail to join the mature peripheral B-cell pool either

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Mitsuharu Yoshiyama,Hidehiro Kakizakiinnate immune cells and stromal cells and are upregulated in response to various danger signals. By bindings to their receptors and signaling for the activation of NF-κB, they regulate multiple aspects of T cell-dependent and -independent antibody responses including B-cell survival, activation, cla

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Reference work 2023Latest editionportant regulator of immunity in both mice and humans. Although much has been learned about its signaling and physiological functions, its complexity in terms of ligand binding, cell-type-specific effects, as well as potential roles in human disease dictates that much work remains to be done in this

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https://doi.org/10.1007/978-981-99-1659-7nce for understanding B-cell biology. Excessive BAFF production is associated with the development of autoimmune disorders such as lupus, a problem attributed to the inappropriate survival of self-reactive B cells. These early findings prompted the development of BAFF inhibitors, which are now in hu

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Pharmacology of the Lower Urinary Tractcal features of systemic lupus erythematosus (SLE) and Sj?gren’s syndrome (SS). Treatment with BLyS antagonists of mice with established SLE ameliorates disease progression and enhances survival. Moreover, similar treatment of mice with inflammatory arthritis ameliorates the ongoing inflammation and

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