| 期刊全稱 | BLyS Ligands and Receptors | | 影響因子2023 | Michael P. Cancro | | 視頻video | http://file.papertrans.cn/181/180128/180128.mp4 | | 發(fā)行地址 | The discovery of BLy..S may lead to therapies for several diseases that involve B cells, including immune deficiencies, autoimmune disease and B cell tumors.Includes supplementary material: | | 學(xué)科分類 | Contemporary Immunology | | 圖書封面 |  | | 影響因子 | Discovery of the BLyS (also known as BAFF) family of ligands and receptors has yielded a paradigm shift in our view of B-lymphocyte selection, survival, activation, and homeostasis. Previously, the B-cell antigen receptor (BCR) was viewed as the sole mediator of these parameters, in which BCR signals were not only dominant but were also linearly related to consequent outcomes. However, appreciating that BLyS signaling is an equal partner in establishing and maintaining B-cell pools in- cated that additional regulatory complexity – apparently based on population density and homeostatic demands – had to be included in models of B-cell behavior. This mounting interest was ampli?ed by evidence of a clear relationship to autoim- nity. The resulting ?urry of research activity has yielded a wealth of information and insights, impacting basic concepts in B-cell tolerance and activation as well as revealing novel translational strategies for autoimmunity, neoplasia, and transplant tolerance. This book includes 12 chapters that together yield an overview of these advances and ideas. The initial excitement generated by associations with humoral autoimmunity, coupled with profound B lineage ph | | Pindex | Book 2010 |
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