Titlebook: Aging; How Science Works Carsten Carlberg,Stine M. Ulven,Eunike Velleuer Textbook 2024 The Editor(s) (if applicable) and The Author(s), und

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https://doi.org/10.1007/978-1-4039-9035-8 and epigenetics, both of which are closely linked. In order to express a gene, ., to transcribe it into RNA, its regulatory regions need to be located within accessible chromatin. Chromatin is the physical representation of epigenetics. In a tissue- and cell type-specific fashion the majority of th

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https://doi.org/10.1007/978-1-349-11114-5rogression of many chronic non-communicable diseases (Chap. .). The latter principles apply also to the process of aging. In this context, we provide an overview on nutrition-sensing pathways and their relation to aging and longevity. The molecular basis of this is the sensing of glucose and amino a

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Guide to Medical Image Analysishagy, loss of proteostasis, stem cell exhaustion, cellular senescence and telomer attrition. Firstly, the handling of oxidative and metabolic stress in mitochondria and the endoplasmatic reticulum via SIRTs, AMPK and the unfolded protein response are discussed. Furthermore, the mechanisms and purpos

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Guide to Medical Image Analysisg and neutralizing pathogens, in order to reduce the global burden of infectious diseases. We distinguish the features and cell types of innate and adaptive immunity and describe their response over time after contact with an antigen. Then, we describe that epigenetic regulation is fundamental for t

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