Titlebook: Autophagy Regulation of Innate Immunity; Jun Cui Book 2019 The Editor(s) (if applicable) and The Author(s), under exclusive license to Spr

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Regulation of Inflammasome by Autophagy,atory cell death called pyroptosis. It is vital for innate immune responses, providing protection against infectious agents, sterile environmental insults, and host cell damages. Aberrant activation of inflammasome is closely correlated with numerous hereditary and acquired inflammatory disorders. T

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The Cross-Regulation Between Autophagy and Type I Interferon Signaling in Host Defense,Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway, which results in the transcription of plentiful IFN-stimulated genes (ISGs) to establish the comprehensive antiviral states. Type I IFN signaling should initiate timely to provoke innate and adaptive immune responses

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Selective Autophagy Regulates Innate Immunity Through Cargo Receptor Network, cellular homeostasis. Autophagy can be highly selective and target specific cargoes by utilizing multiple cargo receptors, which bind both ubiquitinated cargoes and autophagosomes. Mounting evidence has revealed the deep involvement of selective autophagy in innate immunity upon pathogen invasion,

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Targeting Autophagy with Small-Molecule Modulators in Immune-Related Diseases, Of note, autophagy controls intracellular homeostasis and cell responses to stresses by regulating the self-renewal, maturation, and survival of immune cells. And dysregulation of autophagy in immune cells may contribute to the inflammatory disorders and defect in immune responses against invasive

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F. Touati,S. Kahlouche,M. Idresively eliminate microbial invasion and avoid immune-related diseases. Autophagy is a homeostatic process that is critical for the bulk degradation of cellular constituents. Recently, accumulating evidence demonstrates the emerging role of the autophagy in the regulation of innate immune responses. I

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