| 期刊全稱(chēng) | Autoimmunity and the Pathogenesis of Diabetes | | 影響因子2023 | Fredda Ginsberg-Fellner (Professor of Pediatrics, | | 視頻video | http://file.papertrans.cn/167/166160/166160.mp4 | | 學(xué)科分類(lèi) | Endocrinology and Metabolism | | 圖書(shū)封面 |  | | 影響因子 | It has been a challenge for us to edit this volume of Endocrinology and Metabo- lism: Progress in Research and Clinical Practice. The topic of the pathogenesis of insulin-dependent, type I diabetes mellitus is particularly appropriate for this series, since advances in this area have been made, to a large extent, by applying state-of-the-art laboratory techniques to clinical samples. Over the last several years, a number of lines of evidence have been gathered, suggesting that classic type I diabetes mellitus results from the autoimmune des- truction of pancreatic beta-cells in genetically susceptible individuals. This hypothesis is particularly appealing because it offers a rational approach to the prevention of diabetes by immunosuppression. We have tried to present a balanced, authoritative summary of the information currently available to support the autoimmune hypothesis for the pathogenesis of human type I diabetes, to place this information in historical perspective, to include relevant information from animal models of type I diabetes in which more invasive experimentation is ethical, and, finally, to update the reader on the current status of attempts to intervene in the p | | Pindex | Book 1990 |
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