Titlebook: Atlas of Toxicological Pathology; Chirukandath Gopinath,Vasanthi Mowat Book 2014 Springer Science + Business Media New York 2014 administr

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Fundamentals of Mechanical Vibrations two decades, including many biologics. The pathogenesis of these lesions is now being studied more intensively than in the past. In this chapter, mechanisms of toxicity are briefly discussed. Common induced lesions of these organ systems are described, with illustrations and examples of causative agents and their modes of action.

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The Respiratory System, various regions are covered. Examples of test articles causing different lesions are provided. Lesions of the upper respiratory tract in inhalation safety studies are described in some detail, with particular reference to their significance. The mechanisms of toxicity in the various regions of the

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expository

The Endocrine System, and pituitary glands and pancreatic islets. Interrelationships with other endocrine and nonendocrine organs are described. A few induced tumours of the endocrine glands are included, and their relative importance to human safety is discussed.

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The Lymphoid System,ostimulation, immunosuppression, immunogenicity, or hypersensitivity. The changes in lymphoid organs are subject to many environmental factors. Changes in the thymus include apoptosis, atrophy, and a few proliferative responses. The lymph nodes and spleen display increases or decreases in the cellul