Titlebook: Atlas of Pediatric Hepatology; Deirdre Kelly,Khalid Sharif,Jane Hartley Book 2018 Springer International Publishing AG, part of Springer N

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H. Bauer,R. Kurth,H. GelderblomThe spleen should not be palpable under normal circumstances and therefore splenomegaly is an important clinical sign requiring further investigation.

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Particle Models for Low Pressure Plasmas,Abdominal distention in children has a wide differential diagnosis, but may be grouped into Ascites, Neoplasm and Organomegaly. This chapter will mainly focus on of hepato-biliary neoplasms.

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The Acutely Ill Child,The main causes of liver disease in an acutely unwell older child are viral infection, drug injury or metabolic liver disease (Table 5.1). A thorough history may help distinguish from drug or toxin induced liver injury.

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Children with Cancer Who Have Liver Disease,Children with haematological or solid organ malignancies may develop liver involvement due to cytotoxic treatment, an impaired immune system or as part of the complications of bone marrow or stem cell transplantation.

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Diseases with Liver and Kidney Involvement,Many congenital and acquired diseases involve both concomitant kidney and liver disease. In these conditions the rate of disease progression is independent in each organ and a co-ordinated approach between nephrologist and hepatologist is essential for management, particularly when considering a need for combined transplantation.