Titlebook: Ataxia-Telangiectasia; Richard A. Gatti,Robert B. Painter Conference proceedings 1993 Springer-Verlag Berlin Heidelberg 1993 Ataxia-Telang

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Ataxia-Telangiectasia: A Brief Historical Overviewence of the thymic deficiency and suggestion was made that A-T patients may be critical keys to the study of complex host factors involved in immunogenesis and malignancy. In 1968 the peculiar generalized nucleocytomegaly was recognized confirming the fact that A-T is a multisystem disorder..

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Identification of A-T heterozygotesation frequencies than any of the heterozygotes. These studies were on cultured skin fibroblasts (20 heterozygotes and 17 controls for which there was complete discrimination; Parshad ., 1985; Shiloh ., 1986; Shiloh ., 1989) and peripheral blood lymphocytes (9 heterozygotes and 35 controls with over

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Lymphoid V(D)J Recombination: Accessibility and Reaction Fidelity in Normal and Ataxia-Telangiectasie temporal resolution of such studies has been limiting. They have not permitted determination of whether transcription and recombination are consequences of a common chromatin change or whether transcription precedes and, thereby, activates recombination.

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