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Titlebook: Asthma: Targeted Biological Therapies; Girolamo Pelaia,Alessandro Vatrella,Rosario Masell Book 2017 Springer International Publishing Swit

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發(fā)表于 2025-3-21 16:03:34 | 只看該作者 |倒序瀏覽 |閱讀模式
期刊全稱Asthma: Targeted Biological Therapies
影響因子2023Girolamo Pelaia,Alessandro Vatrella,Rosario Masell
視頻videohttp://file.papertrans.cn/164/163550/163550.mp4
發(fā)行地址Describes the rationale, mechanisms of action, and indications for use of biologics in asthma.Offers an excellent balance between basic science and analysis of clinical trials.Includes very clear illu
圖書封面Titlebook: Asthma: Targeted Biological Therapies;  Girolamo Pelaia,Alessandro Vatrella,Rosario Masell Book 2017 Springer International Publishing Swit
影響因子.This book focuses on the fundamentals of the use of biologics in asthma, describing the rationale, principles, mechanisms of action, and indications. It offers an excellent balance between basic science and the analysis of clinical trials, updating readers with new developments that are changing the global scenario for targeted biological anti-asthma therapies, especially with regard to more severe disease. A range of therapies are considered, from the humanized monoclonal anti-IgE antibody omalizumab, widely approved as add-on treatment for inadequately controlled disease, through to emerging biologics for which evidence supportive of efficacy is accumulating, including anti-IL-5, anti-IL-4, and anti-IL-13 therapies. One aspect to emerge is the variability in individual response, which suggests a need for characterization of different asthma subtypes to permit the effective implementation of phenotype-targeted treatments. This book will be of interest for pulmonologists, clinical immunologists, and physicians seeking sound information on these therapies, but also for scientists and pharmacologists wishing to enhance their knowledge of the therapeutic implications of the cellular
Pindex Book 2017
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Girolamo Pelaia,Alessandro Vatrella,Rosario MasellDescribes the rationale, mechanisms of action, and indications for use of biologics in asthma.Offers an excellent balance between basic science and analysis of clinical trials.Includes very clear illu
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http://image.papertrans.cn/b/image/163550.jpg
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https://doi.org/10.1007/978-3-319-46007-9IL-13; IL-4; IL-5; airway remodelling in asthma; anti-IgE; anti-TNFalpha antibodies; cellular and molecula
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978-3-319-83417-7Springer International Publishing Switzerland 2017
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https://doi.org/10.1007/978-3-8348-9214-0airway structural cells, is a hallmark of asthma [1, 2]. Several inflammatory phenotypes of asthma have been characterized, which include eosinophilic, neutrophilic, mixed and paucigranulocytic patterns [3, 4]. Eosinophils are the inflammatory cells most frequently infiltrating the airways of asthma
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https://doi.org/10.1007/978-3-658-30557-4es which involve all layers of the bronchial wall, including large and small airways [1, 2]. Such structural changes, collectively referred as airway remodelling, likely originate from repetitive cycles of tissue injury, causing subsequent cellular responses leading to abnormal repair [3]. Although
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