Titlebook: Asthma: Pathophysiology, Herbal and Modern Therapeutic Interventions; Sheikh Rayees,Inshah Din Book 2021 The Author(s), under exclusive li

Introduction

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https://doi.org/10.1007/978-3-8348-9397-0 the nucleus, binding to its specific DNA sequences and activating transcription of cytokine-responsive genes especially GATA3 (Fig. 6.1) (Zhu et al. 2006). However, the source from which this initial IL-4 is produced that causes the phosphorylation of STAT6, and hence the activation of GATA3 in viv

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https://doi.org/10.1007/978-3-658-37606-2 recombinant protein-based receptor antagonists (e.g., Pitrakinra) and soluble receptors (e.g., Etanercept) (Cook and Bochner 2010). Targeting these cytokines can have a significant impact on pathophysiological features of asthma, which occur as a result of their function. Currently, various anti-as

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Book 2021severity, natural history and hence treatment response. These differences in intensities of various presentations such as bronchial hyper-responsiveness, airway inflammation, mucus production, airflow obstruction make asthma a heterogeneous disease. The mainstay of current therapies for asthma inclu

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Transcription Factors Involved in Th2 Cell Differentiation, the nucleus, binding to its specific DNA sequences and activating transcription of cytokine-responsive genes especially GATA3 (Fig. 6.1) (Zhu et al. 2006). However, the source from which this initial IL-4 is produced that causes the phosphorylation of STAT6, and hence the activation of GATA3 in viv

BOGUS

Current Asthma Treatments,fect on the efficacy of some current asthma drugs especially those that target eosinophilic asthma. The mainstay of current therapies for asthma includes inhaled corticosteroids, phosphodiesterase inhibitors, leukotriene modifiers, and β2-adrenoceptor agonists (Mcgrath et al. 2012; Gibeon and Menzie