Titlebook: Aspartic Proteinases; Retroviral and Cellu Michael N. G. James Book 1998 The Editor(s) (if applicable) and The Author(s), under exclusive l

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Energy Consumption II—Heat Production and enzymes for the mature virus. Hence, it is essential for the maturation and infectivity of the virus and is thus a major target for the development of inhibitor drugs. But these efforts have been handicapped by the development of drug resistant viral strains.

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https://doi.org/10.1007/978-3-658-03521-1ere raised . by passage of HIV-1. in the presence of increasing concentrations of VX-478 and the related hydroxyethylamino sulfonamide inhibitor VB-11,328. By direct PCR analysis of selected viruses, a number of mutations were identified (L10F, M46I,147V, I50V and I84V) in the protease gene. These m

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https://doi.org/10.1007/978-3-658-12181-5us uses for the cleavage of the . and . complex during viral replication.. Many research laboratories have developed HIV-1 PR inhibitors that have become lead compounds for anti-viral drugs. Some of these compounds have been found to stop very effectively the replication of the HIV-1 virus ... Howev

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Vertrieb: Der Schwanz wackelt mit dem Hund,gands can interfere with their catalytic properties. The viral proteinase is responsible for processing of viral polyproteins and is essential for viral particle maturation. Inhibition of the proteinase is therefore an efficient means of preventing viral replication, a principle that is used by the

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Der gewisse Kniff bei Aktienfonds,hesus monkey ... Infection of macaque species with M-PMV causes an AIDS-like disease.. M-PMV is characterized by the self-assembly of the Gag, Gag-Pro and Gag-Pro-Pol precursors into intracytoplasmic particles (procapsids) within the infected cell cytoplasm. These morphogenetic properties of the vir

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https://doi.org/10.1007/978-3-663-10073-7fect cattle in which it induces a disease complex termed enzootic bovine leukosis. Experimental infection of rabbits, however, causes severe depression in. immune function.. Although BLV and HTLV are grouped with C-type oncoviruses, during assembly they can be barely distinguished from lentiviruses,

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