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Titlebook: Aromatase Inhibitors; Barrington J. A. Furr Book 2008Latest edition Birkh?user Basel 2008 Brustkrebs.Drogen.Treatment.biosynthesis.breast

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樓主
發(fā)表于 2025-3-21 18:18:05 | 只看該作者 |倒序瀏覽 |閱讀模式
期刊全稱Aromatase Inhibitors
影響因子2023Barrington J. A. Furr
視頻videohttp://file.papertrans.cn/162/161734/161734.mp4
發(fā)行地址First comprehensive overview on the different aromatase inhibitors.Includes preclinical and clinical studies.Gives outlook on future uses of aromatase inhibitors.International authorship
學(xué)科分類Milestones in Drug Therapy
圖書封面Titlebook: Aromatase Inhibitors;  Barrington J. A. Furr Book 2008Latest edition Birkh?user Basel 2008 Brustkrebs.Drogen.Treatment.biosynthesis.breast
影響因子.Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme‘s trivial name, aromatase)...Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy..
Pindex Book 2008Latest edition
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https://doi.org/10.1007/978-3-319-19393-9gen receptor (ER) with antioestrogens such as tamoxifen, by ovarian ablation using surgery, radiotherapy or luteinising hormone-releasing hormone analogs such as goserelin, or, in postmenopausal women, by blocking oestrogen production by inhibiting aromatase activity [.].
地板
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2296-6056 aromatase inhibitors.International authorship.Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrog
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Urban Land Use Land Cover Changehe sole member of family 19 (see .). This haem protein is responsible for binding of the C19 androgenic steroid substrate and catalyzing the series of reactions leading to formation of the phenolic A ring characteristic of oestrogens.
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發(fā)表于 2025-3-22 18:50:49 | 只看該作者
Management and Industrial Engineeringme. Whereas we now have data available comparing the effect of different compounds on total body aromatase inhibition, our understanding of the effects of these compounds at the tissue level, in particular with respect to local effects in the normal breast as well as breast tumour tissue, is still incomplete.
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發(fā)表于 2025-3-22 23:35:06 | 只看該作者
Clinical pharmacology of aromatase inhibitors,me. Whereas we now have data available comparing the effect of different compounds on total body aromatase inhibition, our understanding of the effects of these compounds at the tissue level, in particular with respect to local effects in the normal breast as well as breast tumour tissue, is still incomplete.
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發(fā)表于 2025-3-23 02:14:14 | 只看該作者
Clinical studies with anastrozole,gen receptor (ER) with antioestrogens such as tamoxifen, by ovarian ablation using surgery, radiotherapy or luteinising hormone-releasing hormone analogs such as goserelin, or, in postmenopausal women, by blocking oestrogen production by inhibiting aromatase activity [.].
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