Titlebook: Aromatase Inhibitors; Barrington J.A. Furr Book 20061st edition Birkh?user Basel 2006 Brustkrebs.Clinical Overview.Clinical Pharmacology.D

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Book 20061st editioner, they were not particularly potent and lacked specificity. However,?second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that?these agents will become the cornerstones of future endocrine therapy..

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Book 20061st editionom the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgen

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