Titlebook: Arachidonic Acid in Cell Signaling; Daniele Piomelli Book 1996 Springer Science+Business Media Dordrecht 1996 biochemistry.cell.chemistry.

人類學家

https://doi.org/10.1007/978-3-662-05807-7biochemistry; cell; chemistry; pharmacology; signal transduction

山羊

978-3-662-05809-1Springer Science+Business Media Dordrecht 1996

WAX

The Arachidonic Acid Cascade,ormational molecules. These signals are essential for the survival of free-living cells and for coordinating the complex needs of multicellular organisms: as adaptive demands and cell functions changed during evolution, they underwent dramatic transformations in their modes of action, and were calle

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chisel

Before Metabolism: Arachidonate as an Intracellular Second Messenger,1950s, the set of experimental criteria originally proposed by Earl Sutherland to define a second messenger molecule are still applicable today. These criteria, listed in Table 3.1, are based on the definition of a second messenger as an endogenous molecule whose role is to transduce within a target

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Arachidonate Metabolism,ies of the enzymatic systems involved in these reactions. As this task will oblige us to go into a considerable amount of factual detail, it may be helpful to begin with a general overview of arachidonate metabolism, whose landmarks are illustrated in Figure 4.1.

搖晃

The Eicosanoids in Cellular Signaling,sponsible for translating receptor occupancy into cellular responses. For example, the binding of dopamine to D.-type receptors on neurons stimulates the activity of the enzyme adenylate cyclase, which catalyzes the conversion of ATP into cyclic AMP. This second messenger, in turn, binds to and acti

Allege

PATHY

Biosynthesis, Storage and Mobilization of Arachidonic Acid, exclusively found in the plasma membrane; a set of enzymes that synthesize this precursor; and a stimulus-activated phos-pholipase that hydrolyzes it, producing one or more metabolites with distinct biological effects.

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