Titlebook: Applied Bioinformatics; An Introduction Paul M. Selzer,Richard J. Marh?fer,Oliver Koch Textbook 2018Latest edition Springer International P

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The Decoding of Eukaryotic Genomes,e first time one could analyze a complete genome, including both genes and their regulatory regions. Three years later, the sequencing of the first multicellular eukaryotic genome, from the nematode .. was completed. Eukaryotic genomes are larger and far more complex than those from bacteria (? Chap

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Protein Structures and Structure-Based Rational Drug Design,ed upon water release) to form a polypeptide (? Chap. .). Polypeptides can range in length from three to several hundred amino acids. The amino acid sequence of a given protein, also known as the primary structure, is genetically determined. It becomes fixed during translation based on the informati

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The Functional Analysis of Genomes,between 30,000 and 35,000. It is known today that the human genome is quite young from a phylogenetic point of view and shows an enormous difference between the number of genes and the size of the genome. It contains 19,000–20,000 genes (Ezkurdia et al. 2014), with an overall size of 3.3 Gigabases (

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Comparative Genome Analyses,ing as well as developments in hardware and software that have made it possible to store and annotate huge amounts of data. The total number of all freely accessible nucleotides in GenBank [genbank], the DNA sequence database at the NCBI, is 218 billion bases within 196 million DNA sequences (Releas

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