Titlebook: Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtu; Michael D. Waters,Stephen Nesnow,Lar

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s important area. Complex mixtures discussed include ambient air and water, waste water, drinking water, shale oil, syn- thetic fuels, automobile exhaust, diesel particulate, coal fly ash, cigarette smoke condensates, and food products. It is our hope that this volume will serve as a refer- ence to catalyze a978-1-4684-3613-6978-1-4684-3611-2

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Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtu978-1-4684-3611-2

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https://doi.org/10.1007/978-1-4899-7537-9onsible for the biological effect may be accumulated. Thus, mutagenicity tests will (d) aid in identifying the specific hazardous compounds involved and in establishing priorities for further valid testing, testing in whole animals, and more definitive chemical analysis and monitoring.

Asymptomatic

Mutagenesis of Mammalian Cells by Chemical Carcinogens after Metabolic Activation are chemically nonreactive and have to be enzymatically activated before they can manifest biological activity (16–17). Furthermore, many mammalian cell lines which are suitable for studies on mutagenesis are not able to metabolically activate these chemicals (18–22).

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Short-Term Bioassay of Complex Organic Mixtures: Part II, Mutagenicity Testingonsible for the biological effect may be accumulated. Thus, mutagenicity tests will (d) aid in identifying the specific hazardous compounds involved and in establishing priorities for further valid testing, testing in whole animals, and more definitive chemical analysis and monitoring.

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