Titlebook: Application of Biological Markers to Carcinogen Testing; Harry A. Milman,Stewart Sell Book 1983 Plenum Press, New York 1983 DNA.Potential.

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Stefan Mahlknecht,Christoph Grimms promoting or enhancing agents which facilitate the development of altered cells into tumors. Effects by chemicals in both sequences can lead to an increase of cancer in animals and, consequently, chemicals can be carcinogenic by a variety of mechanisms.

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The Occurrence Of Neoplasms in Long-Term , Studiesshorten the length of these studies, reduce the cost, or simplify the diagnosis of chemically induced neoplasms would be extremely useful. Any marker will have to be validated by comparing its use to the results of long-term . studies.

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Early Morphologic Markers of Carcinogenicity in Rat Pancreasl in rats. Of these three, the azaserine-rat model has been best characterized and can be regarded as a prototype for carcinogenesis by chemicals that appear primarily to affect acinar cells and lead to their transformation. This model will be described in detail and compared with other models that will be less completely described.

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