Titlebook: Apoptosis, Senescence and Cancer; David A. Gewirtz,Shawn E. Holt,Steven Grant Book 2007Latest edition Humana Press 2007 Tumor.apoptosis.le

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Elements of Applied Bifurcation Theoryresses. MC is characterized by changes in nuclear morphology and the eventual appearance of polyploid cell progeny in affected cell populations, is markedly enhanced in cells lacking p53 function, and is the result of overaccumulation of cyclin B1 in cells delayed late in the cell cycle by the induc

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Introduction to Dynamical Systems,s macromolecules and organelles. During the last decade, progress made in our understanding of the molecular controls of autophagy has uncovered the importance of tumor suppressor molecules in the stimulation of autophagy. Downexpression of autophagy is an early event during tumorigenesis. However,

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https://doi.org/10.1007/978-94-015-0623-6hat prevent infinite proliferation: replicative senescence and stress-induced senescence (SIS). In replicative senescence, failure of the DNA polymerase to faithfully duplicate the chromosomal ends leads to progressive telomeric DNA sequence loss with each subsequent cell division and signaling for

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https://doi.org/10.1007/978-94-011-6427-6ure of cells to ionizing radiation or chemical agents can promote genomic instability, although the mechanisms involved are not understood. Knowledge concerning mechanisms of genomic instability has been derived from studies in yeast and human genetic disease, where mutations in a variety of genes i

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Foundations of Computer Scienceolet light and ionizing radiations or as a consequence of DNA replication or physiological DNA rearrangements. Cells respond to DNA damage by the coordinated induction of cell-cycle arrest and DNA repair or trigger apoptosis if the damage is too extensive. The DNA damage response is induced by two p

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Foundations of Computer Sciencee altered in most tumor types. c-Myc is the founding member of a family of structurally related basic helix-loop-helix-leucine zipper (bHLH-Zip) proteins that function as sequence-specific transcription factors and are aberrantly expressed in most cancers c-Myc is a key regulator of cell proliferati

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Foundations of Computer Sciencedamage response. The phosphorylation of H2AX on Ser 139, named γH2AX, is an early response to the generation of DNA DSBs and extends along megabase-long domains, both sites of the lesion, supporting amplification of signal transduction pathways. In parallel, 53BP1 accumulates on damaged chromatin to