Titlebook: Antisense Research and Application; Stanley T. Crooke Book 1998 Springer-Verlag Berlin Heidelberg 1998 Anti-Sense.Antisense.Oligonuclotide

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https://doi.org/10.1007/b115596d DNA backbones can cause immune activation which is concentration-and length-dependent and sequence-independent. However, the different backbones currently under development for antisense applications differ greatly in the degree to which they induce immune effects. As might be expected, neutral ba

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https://doi.org/10.1007/b115596 (for recent reviews, see Weiss et al. ., .,.; .). The antisense approach has been particularly useful in characterizing the pharmacological properties and biological functions of receptors for neurotransmitters. This is due to the rapid discovery of the molecular structure of new subtypes of neurot

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https://doi.org/10.1007/b115596any cases the stimuli responsible for this change in brain function also activate transcription factors (TF), some of which are of the immediate-early gene (IEG) family. Stimuli of both physiological and pathophysiological significance have been shown to activate the prototypical IEG, c-.. Consequen

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https://doi.org/10.1007/b115596tant tumors. There is an urgent need for therapeutic alternatives aiming at compounds with better tolerability at efficacious doses that are directed at defined, disease-relevant molecular targets. The progress made in understanding the molecular basis of mammalian cell transformation has led to the

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Selected Examples of Spectra of Pairs, at viral penetration and uncoating or viral genome replication, and the era of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) has helped regenerate interest in antiviral drug discovery and development (Table 1). Discovery of many of the active antivirals

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https://doi.org/10.1007/978-3-642-74477-8ells relative to that of normal tissue for their therapeutic indices. Small-molecule chemotherapeutic agents have narrow therapeutic indices for a variety of reasons. The most global reason is simply that small molecules do not specifically target cancer cells. However, in addition cytotoxic agents

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